Founded in 1942 by Felix Fumalfdolf. The Nazis wanted to create an army of werewolves or other superhumans. (those wacky nazis) It was called "Project WOLF"
They eventually capture The Beast and run some experiments on it. (They actually do make it stronger.) It gets pissed and escapes/kills a bunch of people. (also, as a result of the experiments, The Beast decided to kill all werewolves. Which made a lot of werewolves migrate to America)
(present day -20 or so years) Matthias Fumalfdolf discovers his grandfather's work and becomes obsessed with it. (and maybe other occult stuff too) THETA is established in the United States (Trans-Human Genetic Testing and Applications)
After the civil war of the Redmoon pack THETA agents discover a (barely) living werewolf, Kevin, among the dead werewolves. They cover up the whole incident while taking Kevin for research.
Eventually THETA creates werewolf like creatures, many of them have deformities. Very few of them survive.
Shortly before the events of the story a number of THETA creatures escaped the facility , most were captured immediately, many were killed, and very few managed to evade capture. But THETA is still after them, and THETA is more powerful than anyone knows.
This cosmic dance of bursting decadence and withheld permissions twists all our arms collectively. But, if sweetness can win - and it can - then I'll still be here tomorrow, to high five you, yesterday, my friend. Peace.